Semaglutide
medicationA GLP-1 medication that reduces appetite, approved for weight management and type 2 diabetes.
Start with a health goal, then understand the tests, treatments, supplements and emerging compounds people compare, with status and evidence clearly explained. Save anything to My Journal to compare later.
Updated October 7, 2026



A GLP-1 medication that reduces appetite, approved for weight management and type 2 diabetes.
A weekly GIP and GLP-1 medication approved for weight management, sleep apnea and type 2 diabetes.
An older, daily GLP-1 injection for weight management and diabetes, now available as a generic.
An investigational triple-hormone weight-loss drug from Eli Lilly. Not approved; only available in trials.
A cheap, decades-old diabetes pill that some people ask about for weight and healthy aging.
A plant compound sold as a supplement for blood sugar and weight. It is not a GLP-1 drug.
A lab-made peptide popular for injury recovery. Mostly animal data, and not an approved drug.
A synthetic fragment of thymosin beta-4 marketed for recovery. Animal data only; not approved.
A protein supplement made from animal collagen, popular for skin, joints and recovery.
A coenzyme every cell uses for energy; offered as IV drips and injections at longevity clinics.
An NAD+ precursor sold as a supplement. FDA confirmed in 2025 that it can be a supplement again.
A four-amino-acid peptide marketed for aging and sleep. Limited research, not an approved drug.
A peptide encoded by mitochondria, studied in mice for metabolism. Human data are minimal.
A transplant drug some clinicians prescribe off-label for longevity. Human aging data are early.
The body's own sleep-timing hormone, sold as a supplement for jet lag and trouble falling asleep.
A gentle form of magnesium that people take for sleep and relaxation.
A simple amino acid some people take before bed. Evidence comes from a few small studies.
A 1970s "sleep peptide" sold online. Human results were inconsistent and it is not approved.
A Russian nasal peptide marketed for focus. Approved in Russia, not in the US.
A Russian peptide marketed for anxiety and focus. Not approved or compoundable in the US.
An amino acid from tea leaves, often paired with coffee for calm focus.
Fish and algae oils (EPA and DHA) taken for heart and brain health.
A copper peptide common in skin-care serums. Injectable versions are not approved.
A prescription pill that slows male-pattern hair loss by lowering DHT.
A hair-growth drug: topical over the counter, or a low-dose pill prescribed off-label.
A prescription vitamin A cream for acne and sun-related skin aging.
Prescription testosterone replacement for men with confirmed low testosterone.
A pill that can raise a man's own testosterone while preserving fertility. Compounded, not approved.
A reproductive-hormone peptide studied in fertility research. Restricted from compounding.
A peptide that prompts your pituitary to release growth hormone. Available compounded.
An FDA-approved growth-hormone-releasing peptide for belly fat in people with HIV.
The most researched sports supplement, for strength and power; brain effects are being studied.
A growth-hormone-releasing peptide sold online for body composition. Not approved.
A long-acting growth-hormone-releasing peptide sold online, often with ipamorelin. Not approved.
An essential vitamin for bones and muscles; worth testing before you supplement.
Live microbes in supplements and foods. Benefits depend heavily on the specific strain.
An amino acid that fuels gut-lining cells; taken for "leaky gut" and recovery.
A soluble fiber for regularity that also modestly lowers LDL cholesterol.
An investigational long-acting amylin analog being studied alone and with semaglutide.
An investigational glucagon and GLP-1 receptor agonist studied for obesity and liver disease.
A glucagon and GLP-1 receptor agonist approved in China but not approved in the US.
An investigational amylin-receptor agonist being studied by Eli Lilly for obesity.
A modified growth-hormone fragment promoted for fat loss without an FDA-approved use.
An FDA-approved prescription medicine also sold online as unapproved RUO material under PT-141.
An FDA-approved implant for erythropoietic protoporphyria, distinct from online tanning products.
An unapproved pigment-stimulating peptide sold online for tanning and sexual effects.
An FDA-approved medicine for Barth syndrome also sold online as unapproved SS-31.
An immune-signaling peptide approved in some countries but not FDA-approved in the US.
An investigational small-molecule weight-loss drug often grouped into RUO peptide catalogs.
A prescription fertility hormone that is also misrepresented in RUO and weight-loss markets.
A hospital obstetric medicine also promoted in unapproved nasal and wellness products.
An injectable peptide mixture used in some countries but not FDA-approved in the US.
A long-acting laboratory analog of IGF-1 with no FDA-approved human use.
A prescription pill for erectile dysfunction and an enlarged prostate (BPH), sold as Cialis and generics.
The first prescription pill for erectile dysfunction, sold as Viagra and widely as a generic.
A prescription prostate drug that lowers DHT, used off-label in the US for male pattern hair loss.
The main estrogen used in menopause hormone therapy, as pills, patches, gels, sprays and vaginal forms.
A prescription hormone that protects the uterine lining during estrogen therapy and supports fertility treatment.
Synthetic thyroid hormone (T4), the standard prescription treatment for an underactive thyroid.
A prescription fertility pill that helps trigger ovulation; also used off-label for men.
A heart and blood pressure pill, also used off-label for hormonal acne and hair loss in women.
An over-the-counter vitamin A ingredient in skin care, a gentler and weaker cousin of prescription tretinoin.
An Ayurvedic herb sold as a supplement for stress and sleep, with small trials and rare liver injury reports.
A well-absorbed form of magnesium, sold as a supplement and as an over-the-counter laxative.
Fibers such as inulin, FOS and GOS that feed beneficial gut bacteria. Not the same as probiotics.
An essential vitamin for nerves and red blood cells; low levels are common in older adults and metformin users.
A mineral supplement for iron deficiency, best taken after a ferritin or blood test confirms a need.