No. 028medication

Enclomiphene

Enclomiphene is a medication that is compounded, prescription only, not FDA-approved.

Also known as Enclomiphene citrate, Androxal

Enclomiphene is one half of clomiphene, a fertility drug. It blocks estrogen feedback in the brain so the body makes more of its own testosterone, which is why men who want to keep fertility ask about it.

Where to buy: 6 options, from From $42/mo + membership

In 1 example journal

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Compounded · Prescription

Is Enclomiphene FDA-approved?

Made by a licensed compounding pharmacy for an individual prescription. Compounded drugs are not FDA-approved, so quality depends on the pharmacy. Not FDA-approved (the original developer's applications did not win approval). Enclomiphene citrate is in FDA's 503A Category 1 (under evaluation), so pharmacies can compound it for an individual prescription under FDA's interim policy.

As of September 23, 2026.

Key takeaways

Enclomiphene is a pill that signals your brain to tell the testes to make more of their own testosterone.
Unlike testosterone therapy, trials found it kept sperm counts steady.
It is not FDA-approved. FDA turned down its application in 2015, and it is only available compounded.
Its compounding status is uncertain: an FDA advisory committee voted in 2022 against adding it to the permanent list.

How does Enclomiphene work?

Enclomiphene is one half of clomiphene, an older fertility drug. It blocks estrogen's "slow down" signal in the brain, so the pituitary releases more LH and FSH. Those hormones tell the testes to make more testosterone and keep making sperm.

Because it depends on the brain-to-testes signal, it only makes sense when the testes can still respond. It is not expected to help when the testes themselves are the problem.

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A warm, softly lit close-up of a caregiver's hand resting on a senior adult's forearm during a blood-pressure cuff check; cropped, no faces visible.

A clear pill bottle with a black cap, a blank white label, and cream-colored capsules against a bright pale-yellow background.

What does the evidence say about Enclomiphene?

Moderate human evidence

Randomized trials, including phase 3, show it raises testosterone levels and preserves sperm counts; evidence on symptoms and long-term safety is limited.

What to expect

What trials and prescribing information measured over time. Everyone responds differently.

About 6 weeks
In early trials, testosterone and LH levels had risen within about six weeks.
About 3 to 4 months
In phase 3 trials, average testosterone was in the normal range at about 16 weeks, and sperm counts were stable or slightly higher. Effects on symptoms were not well measured.

What do clinicians say about Enclomiphene?

Clinicians see enclomiphene as a way to raise testosterone while protecting fertility, but it has no FDA approval and limited long-term data, and its compounding status could change.

The AUA guideline says clinicians may use selective estrogen receptor modulators (the drug class enclomiphene belongs to), hCG or aromatase inhibitors in men with low testosterone who want to keep their fertility. This is off-label use, and the guideline does not name enclomiphene.
AUA: Testosterone Deficiency guideline (2018, validity confirmed 2024)
Enclomiphene citrate is in Category 1 (under evaluation) on FDA's 503A list dated May 14, 2026, which is why pharmacies can compound it for now.
FDA: 503A bulk drug substance categories list (May 14, 2026)
In a phase 3 program, enclomiphene raised testosterone into the normal range while sperm counts held steady; in the same studies, testosterone gel lowered sperm counts.
Enclomiphene phase 3: raises testosterone and preserves sperm counts (BJU Int 2016)
Clomiphene-type drugs are prohibited at all times in tested sport under the WADA list.
WADA 2026 Prohibited List (as published in the Austrian Federal Law Gazette)

Summaries of published guidelines, drug labels, regulators and reviews, each attributed to its source. DiscoverMedica does not employ clinicians.

Is Enclomiphene right for you, and who should avoid it?

Often considered for

Men with symptoms and low testosterone where the pituitary signal is low or normal (secondary hypogonadism)
Men with low testosterone who want to keep their fertility

Not a fit, or needs extra care

Men whose testes cannot make testosterone (primary hypogonadism), since the drug works through the testes
Anyone with a history of blood clots, a known risk with clomiphene-type drugs
Anyone who notices vision changes on it should stop and call their prescriber
Women and anyone under 18
Competitive athletes in tested sport

Only a licensed clinician who knows your history can decide whether it is right for you.

What are the risks and side effects of Enclomiphene?

Reported side effects include headache, hot flashes, mood changes and nausea; visual disturbances are a known concern with clomiphene-type drugs.
Clomiphene-type drugs carry a risk of blood clots.
Compounded products are not FDA-reviewed, so quality depends on the pharmacy.
It does not work for men whose testes cannot make testosterone (primary hypogonadism).

What should you ask a clinician about Enclomiphene?

Is my low testosterone the kind enclomiphene can address?
How does it compare with clomiphene or TRT for me?

These save with the compound when you add it to My Journal, so they’re on the printout for your visit.

How do people get Enclomiphene through telehealth?

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Complete an online questionnaire about symptoms, history and fertility plans.
Do a baseline hormone test, usually an at-home kit or a lab draw; some programs accept recent labs.
A licensed clinician reviews your results. Some states require a video visit.
If prescribed, a compounding pharmacy ships the capsules to you.
Expect a recheck of hormone levels after a few months.

Labs you may be asked for

Total testosterone
LH and FSH
Estradiol
Sometimes a blood count and PSA

Check your levels first

Some services let you order common lab tests yourself, so the results are ready for your visit. Your clinician decides which labs, if any, you need, and what the results mean.

Function HealthAnnual membership for broad lab panels, drawn at Quest sites or at home.
Visit
Quest HealthOrder individual lab tests from Quest Diagnostics online, without a doctor’s visit.
Visit

From each service’s own site, checked September 23, 2026.

How some providers do it

HimsHealth intake, then an at-home lab kit returned to a certified lab, then provider review. The page describes checking levels again about three months in.
MaximusIntake form and at-home lab test before a doctor finalizes the prescription; recent outside labs are often accepted.

From each provider’s own site, checked September 23, 2026. Programs change, so confirm the details before you sign up.

Where can I get Enclomiphene?

6 providers list Enclomiphene on DiscoverMedica, lowest listed price first.

Hone HealthCompounded enclomiphene

Compounded, not FDA-approvedLowest listed priceClinician consult required

From $42/mo + membershiplisted price†

Start at Hone Health

HealthspanCompounded enclomiphene