Metformin
medicationA cheap, decades-old diabetes pill that some people ask about for weight and healthy aging.
Preventive health, heart and bone health, and what the evidence says about popular longevity compounds.
15 compounds: 3 FDA-approved, 2 compounded, 5 over the counter, 5 research only.
Updated October 7, 2026

compounds for healthy aging & prevention, each with its US status
licensed providers list at least one of them
sold over the counter, no prescription needed




A cheap, decades-old diabetes pill that some people ask about for weight and healthy aging.
A coenzyme every cell uses for energy; offered as IV drips and injections at longevity clinics.
An NAD+ precursor sold as a supplement. FDA confirmed in 2025 that it can be a supplement again.
A four-amino-acid peptide marketed for aging and sleep. Limited research, not an approved drug.
A peptide encoded by mitochondria, studied in mice for metabolism. Human data are minimal.
A transplant drug some clinicians prescribe off-label for longevity. Human aging data are early.
Fish and algae oils (EPA and DHA) taken for heart and brain health.
A peptide that prompts your pituitary to release growth hormone. Available compounded.
A long-acting growth-hormone-releasing peptide sold online, often with ipamorelin. Not approved.
An essential vitamin for bones and muscles; worth testing before you supplement.
An FDA-approved medicine for Barth syndrome also sold online as unapproved SS-31.
An immune-signaling peptide approved in some countries but not FDA-approved in the US.
A long-acting laboratory analog of IGF-1 with no FDA-approved human use.
An essential vitamin for nerves and red blood cells; low levels are common in older adults and metformin users.
A mineral supplement for iron deficiency, best taken after a ferritin or blood test confirms a need.

The compounds patients most often ask us about, grouped by how much evidence stands behind them. Bring this list to your first visit.