Goal · 02

Healthy aging & prevention

Preventive health, heart and bone health, and what the evidence says about popular longevity compounds.

15 compounds: 3 FDA-approved, 2 compounded, 5 over the counter, 5 research only.

Updated October 7, 2026

A man walks away along a bright green tree-lined park path in daylight, carrying a jacket over his shoulder; back turned, no face visible.

compounds for healthy aging & prevention, each with its US status

licensed providers list at least one of them

%

sold over the counter, no prescription needed

15 compounds

Metformin

medication

A cheap, decades-old diabetes pill that some people ask about for weight and healthy aging.

PrescriptionModerate human evidence
12 providers

NAD+

supplement

A coenzyme every cell uses for energy; offered as IV drips and injections at longevity clinics.

Compounded prescriptionEmerging evidence
6 providers

NMN

supplement

An NAD+ precursor sold as a supplement. FDA confirmed in 2025 that it can be a supplement again.

No prescriptionEmerging evidence
7 providers

Epitalon

peptide

A four-amino-acid peptide marketed for aging and sleep. Limited research, not an approved drug.

Research onlyAnimal & lab studies only
Education only

MOTS-c

peptide

A peptide encoded by mitochondria, studied in mice for metabolism. Human data are minimal.

Research onlyAnimal & lab studies only
Education only

Rapamycin

medication

A transplant drug some clinicians prescribe off-label for longevity. Human aging data are early.

PrescriptionEmerging evidence
4 providers

Fish and algae oils (EPA and DHA) taken for heart and brain health.

No prescriptionModerate human evidence
16 providers

Sermorelin

peptide

A peptide that prompts your pituitary to release growth hormone. Available compounded.

Compounded prescriptionEmerging evidence
7 providers

CJC-1295

peptide

A long-acting growth-hormone-releasing peptide sold online, often with ipamorelin. Not approved.

Research onlyAnimal & lab studies only
Education only

Vitamin D

supplement

An essential vitamin for bones and muscles; worth testing before you supplement.

No prescriptionModerate human evidence
17 providers

An FDA-approved medicine for Barth syndrome also sold online as unapproved SS-31.

PrescriptionModerate human evidence
1 provider

An immune-signaling peptide approved in some countries but not FDA-approved in the US.

Research onlyEmerging evidence
Education only

IGF-1 LR3

peptide

A long-acting laboratory analog of IGF-1 with no FDA-approved human use.

Research onlyAnimal & lab studies only
Education only

Vitamin B12

supplement

An essential vitamin for nerves and red blood cells; low levels are common in older adults and metformin users.

No prescriptionStrong human evidence
16 providers

Iron

supplement

A mineral supplement for iron deficiency, best taken after a ferritin or blood test confirms a need.

No prescriptionStrong human evidence
16 providers
Example journals

Journals for healthy aging.

A bright white sunroom filled with potted palms and daylight streaming through tall windows, clean and airy.
a longevity clinic
From a clinician
Example

Healthy aging: the conversation starters

The compounds patients most often ask us about, grouped by how much evidence stands behind them. Bring this list to your first visit.

Omega-3 fatty acidsVitamin DCreatine monohydrateNAD+Rapamycin+1 more