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Goal · 01

Weight & metabolism

GLP-1 medications, metabolic support and the supplements people ask about alongside them.

15 compounds: 5 FDA-approved, 2 over the counter, 8 research only.

Weight checklist Start My Journal

Updated September 28, 2026

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compounds for weight & metabolism, each with its US status

licensed providers list at least one of them

%

sold over the counter, no prescription needed

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15 compounds

Semaglutide

medication

A GLP-1 medication that reduces appetite, approved for weight management and type 2 diabetes.

PrescriptionStrong human evidence
24 providers

Tirzepatide

medication

A weekly GIP and GLP-1 medication approved for weight management, sleep apnea and type 2 diabetes.

PrescriptionStrong human evidence
22 providers

Liraglutide

medication

An older, daily GLP-1 injection for weight management and diabetes, now available as a generic.

PrescriptionStrong human evidence
12 providers

An investigational triple-hormone weight-loss drug from Eli Lilly. Not approved; only available in trials.

Research onlyEmerging evidence
Education only

Metformin

medication

A cheap, decades-old diabetes pill that some people ask about for weight and healthy aging.

PrescriptionModerate human evidence
12 providers

Berberine

supplement

A plant compound sold as a supplement for blood sugar and weight. It is not a GLP-1 drug.

No prescriptionEmerging evidence
13 providers

MOTS-c

peptide

A peptide encoded by mitochondria, studied in mice for metabolism. Human data are minimal.

Research onlyAnimal & lab studies only
Education only

An FDA-approved growth-hormone-releasing peptide for belly fat in people with HIV.

PrescriptionModerate human evidence
1 provider

Psyllium

supplement

A soluble fiber for regularity that also modestly lowers LDL cholesterol.

No prescriptionStrong human evidence
10 providers

An investigational long-acting amylin analog being studied alone and with semaglutide.

Research onlyEmerging evidence
Education only

An investigational glucagon and GLP-1 receptor agonist studied for obesity and liver disease.

Research onlyEmerging evidence
Education only

Mazdutide

peptide

A glucagon and GLP-1 receptor agonist approved in China but not approved in the US.

Research onlyEmerging evidence
Education only

An investigational amylin-receptor agonist being studied by Eli Lilly for obesity.

Research onlyEmerging evidence
Education only

AOD-9604

peptide

A modified growth-hormone fragment promoted for fat loss without an FDA-approved use.

Research onlyEmerging evidence
Education only

Tesofensine

medication

An investigational small-molecule weight-loss drug often grouped into RUO peptide catalogs.

Research onlyEmerging evidence
Education only
Example journals

Journals for weight.

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Dana
Personal list
Example

Starting a GLP-1, thoughtfully

Everything I want to talk through with a clinician before starting a GLP-1, plus the basics I keep reading I should not skip.

SemaglutideTirzepatidePsylliumCreatine monohydrateVitamin D