a men’s health clinician
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TestosteroneEnclomipheneVitamin DKisspeptin-10
No. 029peptide
Kisspeptin-10
Kisspeptin-10 is a peptide that is research only, not approved for human use in the US.
Also known as Kisspeptin, Metastin 45-54, KP-10
Kisspeptin is a natural hormone that switches on the reproductive hormone cascade. Kisspeptin-10 is a short fragment used in academic fertility research, and it is sold online for testosterone and libido.
In 1 example journal
Not approved for human useNot approved for human use in the US. We list it so you can learn what it is, but we do not link to anyone selling it. If you are considering it, a clinician can talk through approved alternatives.
Is Kisspeptin-10 legal in the US?
Not approved for human use in the US. We list it so you can learn what it is, but we do not link to anyone selling it. Not FDA-approved and still in FDA's 503A Category 2 (significant safety risks) as of May 2026, so pharmacies should not compound it.
As of September 23, 2026.
Key takeaways
- Kisspeptin is a natural hormone that switches on the reproductive hormone chain. Kisspeptin-10 is a short fragment used in academic research.
- It is still on FDA's list of substances that raise significant safety risks for compounding.
- Academic studies, many from Imperial College London, are exploring it for fertility and low sexual desire. None has led to an approved use.
- It is banned in sport for men.
How does Kisspeptin-10 work?
Proposed from lab and animal studiesKisspeptin acts on nerve cells in the hypothalamus that release GnRH, which in turn prompts the pituitary to release LH and FSH, the hormones that drive testosterone, sperm and egg production.
In short human research studies, kisspeptin-10 raised LH, and continuous exposure raised testosterone in healthy men. Researchers also note its effects can fade with repeated use.
What does the evidence say about Kisspeptin-10?
Emerging evidenceControlled human research studies show it stimulates reproductive hormones in the short term; there are no approved uses and no long-term trials.
Why are clinicians and regulators cautious about Kisspeptin-10?
Kisspeptin is a serious research target with promising early human studies, but regulators see no safe consumer route today.
FDA placed kisspeptin-10 in Category 2 in 2023, citing possible immune reactions and no, or only limited, safety information. It remains there on the May 2026 list.
FDA: Bulk drug substances that may present significant safety risks (Category 2)Imperial College London researchers studied kisspeptin in 32 women and 32 men with low sexual desire and described the results as proof of concept, with larger studies needed.
Imperial College London: Kisspeptin hormone injection could treat low sex drive (Feb 2023)Research reviews describe kisspeptin as a potential IVF trigger that may lower the risk of ovarian hyperstimulation, but these uses remain investigational.
Novel therapeutic avenues for kisspeptin (Curr Opin Pharmacol 2022)The WADA 2026 list prohibits kisspeptin and its analogues in men as testosterone-stimulating peptides.
WADA 2026 Prohibited List (as published in the Austrian Federal Law Gazette)
Summaries of published guidelines, drug labels, regulators and reviews, each attributed to its source. DiscoverMedica does not employ clinicians.
Who should avoid Kisspeptin-10?
Especially important to avoid if
- Anyone considering buying it online: it is not made to drug standards
- Pregnancy, or anyone with a hormone-sensitive condition
- Men in tested sport
What are the risks and side effects of Kisspeptin-10?
- Not approved for human use. Products sold online as "research chemicals" are not made to drug standards, so identity, purity, sterility and dose are unverified.
- FDA cited immunogenicity risks and limited safety data.
- Its hormonal effects may fade with continuous use in studies.
What should you ask a clinician about Kisspeptin-10?
- What approved options exist for my hormone or fertility goals?
- Is there a clinical trial I could join?
These save with the compound when you add it to My Journal, so they’re on the printout for your visit.
Where can I get Kisspeptin-10?
Kisspeptin-10 is not approved for human use, so DiscoverMedica links to no seller.
We don’t link to sellers of research-only compounds. Products sold “for research use only” are not made for people and are not held to pharmaceutical quality standards.
Compare and learn
Kisspeptin-10: questions, answered
Can kisspeptin raise testosterone?
Short research studies show it can raise reproductive hormones, but there are no approved uses and no long-term trials.
Is it used in IVF?
Only in research studies so far. It is not an approved fertility treatment.
Can I get it from a telehealth provider?
No. Kisspeptin-10 is not FDA-approved and has no lawful compounding route, so there is nothing a licensed telehealth provider can legitimately prescribe. If a site offers it, treat that as a warning sign. DiscoverMedica does not link to anyone selling it.
How can I take part in research?
Ask a reproductive endocrinologist, or search ClinicalTrials.gov for kisspeptin studies.
Important safety information
Kisspeptin-10 is not approved for human use in the US. Not approved for human use in the US. We list it so you can learn what it is, but we do not link to anyone selling it.
Key risks
- Not approved for human use. Products sold online as "research chemicals" are not made to drug standards, so identity, purity, sterility and dose are unverified.
- FDA cited immunogenicity risks and limited safety data.
- Its hormonal effects may fade with continuous use in studies.
Avoid it especially if
- Anyone considering buying it online: it is not made to drug standards
- Pregnancy, or anyone with a hormone-sensitive condition
- Men in tested sport
This is not a complete list of risks. Talk to a licensed clinician or pharmacist about your own situation. If you have a severe reaction, call 911. You can report side effects to the FDA through MedWatch at 1-800-FDA-1088.
Sources
- PubChem: Kisspeptin-10 (CID 25240297)
- FDA: Bulk drug substances that may present significant safety risks (Category 2)
- Kisspeptin and neurokinin B: roles in reproductive health (Physiol Rev 2025)
Also checked for this guide
- FDA: 503A bulk drug substance categories list (May 14, 2026)
- WADA 2026 Prohibited List (as published in the Austrian Federal Law Gazette)
- Imperial College London: Kisspeptin hormone injection could treat low sex drive (Feb 2023)
- Kisspeptin and limbic brain activity in men (JCI 2017)
- Novel therapeutic avenues for kisspeptin (Curr Opin Pharmacol 2022)
- Kisspeptin-10 and LH secretion in healthy men (2011)
Guide reviewed September 23, 2026.
Educational information only, not medical advice. It does not replace a conversation with a licensed clinician.
Example journals
Journals with Kisspeptin-10.
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