NAD+ is a supplement that is compounded, prescription only, not FDA-approved.
Also known as Nicotinamide adenine dinucleotide, NAD, NAD+ IV, NAD+ injection
NAD+ is a molecule cells need to turn food into energy, and levels tend to fall with age. Clinics offer it by IV infusion or injection, and supplement makers sell precursors (NMN, NR) that the body can convert into NAD+.
In 1 example journal
Made by a licensed compounding pharmacy for an individual prescription. Compounded drugs are not FDA-approved, so quality depends on the pharmacy. Not FDA-approved. NAD sits in FDA's 503A "Category 1" (under evaluation), so licensed pharmacies can compound it for an individual prescription under FDA's interim policy. Oral NAD+ products are also sold as supplements.
As of September 23, 2026.
Key takeaways
NAD+ (nicotinamide adenine dinucleotide) is a helper molecule your cells use to turn food into energy, repair DNA and send internal signals. The theory behind boosting it is that restoring youthful levels might support healthier aging.
Injections and IV infusions deliver NAD+ directly. Oral products are usually precursors like NMN or NR, which the body converts. Raising blood levels has been shown; turning that into health benefits has not.
Human studies show NAD+ and its precursors can raise NAD levels in blood, but a 2024 systematic review found little consistent evidence of clinical benefit.
Clinicians describe NAD+ therapy as biologically plausible but unproven. Because it is compounded, product quality depends on the pharmacy.
NAD is in Category 1 on FDA's 503A list, meaning FDA is still evaluating it and allows pharmacies to compound it under interim conditions. That is not an approval.
FDA: 503A bulk drug substance categories list (May 14, 2026)A 2024 systematic review found oral NAD supplementation had few side effects but called for further studies to show clinical benefit. It included no IV studies.
Safety and effectiveness of NAD in different clinical conditions: systematic review (2024)In October 2025 FDA classified a recall of an NAD+ injection product as Class I because of high endotoxin levels, which can cause fever, shock or sepsis.
HMP Global: FDA Class I recall of NAD+ for injection over endotoxin levels (Oct 2025)Telehealth providers that sell NAD+ state on their own pages that it is not FDA-approved for any indication and that FDA does not review compounded drugs.
Eden: NAD+Summaries of published guidelines, drug labels, regulators and reviews, each attributed to its source. DiscoverMedica does not employ clinicians.
Only a licensed clinician who knows your history can decide whether it is right for you.
These save with the compound when you add it to My Journal, so they’re on the printout for your visit.
Complete an online health questionnaire. Some programs add a live video visit.
A licensed clinician reviews your history, interactions and reasons for trying it.
If prescribed, a licensed compounding pharmacy prepares it and ships it to you with supplies.
Check in with the care team by message; plans are usually monthly or multi-month.
From each provider’s own site, checked September 23, 2026. Programs change, so confirm the details before you sign up.
6 providers list NAD+ on DiscoverMedica, lowest listed price first.
† Prices as listed by the provider when we checked; they change.
Listed prices run from $75 to $199 a month across 3 providers, as checked October 7, 2026.
Prices as listed by the provider when we checked; they change. Membership or consult fees may be separate; see each provider.
That has not been shown in people. Studies show NAD+ and its precursors raise NAD levels in the blood, but clear health benefits have not been established.
There is no good comparison. IV and injections are compounded prescriptions. Oral precursors like NMN are sold as supplements. Ask your clinician what you would measure to know whether it is doing anything.
Short-term studies report few serious effects, though IV infusions often cause flushing, nausea or chest tightness. Long-term effects are unknown, and sterility depends on the pharmacy.
Yes. Several telehealth providers prescribe compounded NAD+ injections after an online intake.
This is not a complete list of risks. Talk to a licensed clinician or pharmacist about your own situation. If you have a severe reaction, call 911. You can report side effects to the FDA through MedWatch at 1-800-FDA-1088.
Guide reviewed September 23, 2026.
Educational information only, not medical advice. It does not replace a conversation with a licensed clinician.
The compounds patients most often ask us about, grouped by how much evidence stands behind them. Bring this list to your first visit.
A cheap, decades-old diabetes pill that some people ask about for weight and healthy aging.
An NAD+ precursor sold as a supplement. FDA confirmed in 2025 that it can be a supplement again.
A four-amino-acid peptide marketed for aging and sleep. Limited research, not an approved drug.
A peptide encoded by mitochondria, studied in mice for metabolism. Human data are minimal.